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. 2022 Oct 27;12:18116. doi: 10.1038/s41598-022-21425-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TnC biosensor expression and integration does not impact sarcomere function during a twitch contraction. (A) Ensemble average of normalized (0–100%) amplitude of sarcomere length changes during a single twitch contraction for non-transgenic (black) and transgenic (green) isolated FDB fibers. (B) Summary statistics of baseline sarcomere length from non-transgenic and transgenic isolated FDB fibers show there is no significant difference between groups. (C) Summary statistics for the peak sarcomere length from non-transgenic and transgenic isolated FDB fibers demonstrate there is no significant difference between groups. (D) Summary statistics for the time to peak from non-transgenic and transgenic isolated FDB fibers demonstrate there is no significant difference between groups. (E) Summary statistics for the time to 50% of baseline in isolated FDB fibers from non-transgenic and transgenic animals show no significant difference between groups. Myofibers measured at room temperature with 0.2 Hz stimulation, NTg: n = 19 fibers from n = 3 animals and Tg: n = 26 fibers from n = 7 animals. Mean ± S.E.M. are presented, *P < 0.05.