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. 2022 Oct 27;13:6408. doi: 10.1038/s41467-022-34258-w

Fig. 7. Intestinal FXR mediates the hepatic T3 effect on the GLP-1 production and glucose homeostasis.

Fig. 7

a Relative mRNA levels of Gcg in the ileum of Floxed and IFXRKO mice treated with MMI or both MMI and 5 days of T3 (n = 5). b Plasma active GLP-1, plasma insulin, and blood glucose levels in Floxed and IFXRKO mice treated with MMI or both MMI and 5 days of T3 (n = 6). c oGTT for Floxed and IFXRKO mice treated with MMI or MMI and 5 days of T3 (left) and the AUC for oGTT (right) (n = 6). d Relative mRNA levels of Gcg in the ileum and plasma active GLP-1 levels of Floxed and IFXRKO mice treated with MMI or MMI and 5 days of MB (n = 5). e Plasma insulin, and blood glucose levels in Floxed and IFXRKO mice treated with MMI or MMI and 5 days of MB (n = 6). f oGTT for Floxed and IFXRKO mice treated with MMI or MMI and 5 days of MB (left) and the corresponding AUC for oGTT (right) (n = 6). g Plasma active GLP-1, plasma insulin, blood glucose levels and BW of MMI mice treated with T3 and FEX for 5 days as indicated (n = 5–6). Means ± SEM are shown. P values were calculated by two-tailed unpaired Student’s t test. ns, not significant. Source data are provided as a Source Data file.