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. 2022 Apr 28;29(11):2177–2189. doi: 10.1038/s41418-022-01007-x

Fig. 1. LRPPRC promoted 5FU chemoresistance in the context of P53 mutation.

Fig. 1

A Schematic diagram of the experimental design. B Heatmap of differentially expressed proteins from protein quantitative mass spectrometry. C Immunoblotting of LRPPRC and P53 in SW480 and HCT116 cells treated with 5FU for 36 h. D Immunoblotting of LRPPRC and P53 in SW480 and HCT116 cells treated with DDP for 24 h. E The IC50 values of SW480 and HCT116 cells with or without LRPPRC knockdown. F The combined treatment effect of 5FU and Si-LRPPRC.