FIGURE 2.

Sustained reversal deficit in time-based PRL in MK-801. (A) Proportion of correct responses in saline (black) and MK-801 (red) for individual reversal blocks. Data show mean ± SEM. Note the sustained effect of MK-801 in multiple reversals (red line, blocks 2-4) (for stats, see Table 1). (B) Single rat’s performance; trace shows a smoothed proportion of correct lever responses in saline (top) and MK-801 (below). Tick marks above and below each graph indicate right and left lever presses, respectively. Vertical dashed lines indicate reversals. (C) Proportion of perseverative and regressive errors in reversal blocks 2–6 (for stats, see Table 1). (D) Early and late trial performance measured as the proportion of correct lever presses collapsed over the whole session. (E) Same as in D, but for individual reversal blocks (for stats, see Table 1). (F) Proportion of correct responses for individual animals, stratified based on MK-801 block 1 performance (p (correct) > 0.5, top and p (correct) < 0.5 bottom). Dashed circles indicate selection criterion. (G) Probability of staying at the same lever after rewarded (win) and unrewarded trials (loss). (H) Conditional probability to stay after loss trials dependent on optimal and suboptimal choice. (I) Choice preference for optimal and suboptimal levers measured as the difference between the conditional staying probability (optimal–suboptimal) shown in (H). (J) Same as J, but for performance-based PRL. *p < 0.05, **p < 0.001, ****p < 0.0001 (see Table 1 for statistical results).