TABLE 1.
Summary statistics.
| Figure | Variable | n | Measure 1 | Measure 2 | Test/Statistic | p-value | Adjusted | Signif. | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| p-value (Holm) | |||||||||||
| Figure 2 | A | p(correct) | Saline | SE | MK-801 | Paired Wilcoxon | |||||
| Mean | Mean | signed rank test | |||||||||
| 1 | 30 | 0.77 | 0.03 | 0.6 | 0.05 | 368 | 0.004 | 0.016 | * | ||
| 2 | 30 | 0.78 | 0.02 | 0.42 | 0.05 | 445 | 6.91e-7 | 4.15e-6 | **** | ||
| 3 | 30 | 0.81 | 0.02 | 0.65 | 0.05 | 366 | 0.005 | 0.016 | * | ||
| 4 | 30 | 0.83 | 0.02 | 0.63 | 0.04 | 397 | 3.8e-4 | 1.9e-4 | ** | ||
| 5 | 30 | 0.79 | 0.02 | 0.72 | 0.03 | 299 | 0.08 | 0.16 | ns | ||
| 6 | 30 | 0.77 | 0.04 | 0.73 | 0.03 | 316 | 0.088 | 0.16 | ns | ||
| Figure 2 | A | Order effects | Saline | Saline | Wilcoxon rank | ||||||
| of treatment | Day 1 | Day 2 | sum test | ||||||||
| 15 | 0.81 | 0.01 | 0.79 | 0.01 | 155 | 0.082 | ns | ||||
| MK-801 | MK-801 | Wilcoxon rank | |||||||||
| Day1 | Day2 | sum test | |||||||||
| 15 | 0.63 | 0.01 | 0.67 | 0.01 | 68 | 0.068 | ns | ||||
| Figure 2 | C | p | n | Saline | IQR | MK-801 | IQR | Paired Wilcoxon | p-value | Adjusted | Signif |
| (perseverative errors) | Median | Median | signed rank test | p-value (Holm) | |||||||
| 2 | 30 | 0.06 | 0.09 | 0.61 | 0.61 | 34 | 4.7e-5 | 2.32e-4 | **** | ||
| 3 | 30 | 0.06 | 0.09 | 0.08 | 0.56 | 112 | 0.023 | 0.069 | ns | ||
| 4 | 30 | 0.04 | 0.06 | 0.20 | 0.37 | 73 | 6.1e-4 | 0.002432 | ** | ||
| 5 | 30 | 0.07 | 0.09 | 0.08 | 0.24 | 182.5 | 0.309 | 0.5 | ns | ||
| 6 | 30 | 0.10 | 0.13 | 0.10 | 0.19 | 152 | 0.25 | 0.5 | ns | ||
| p | n | Saline | IQR | MK-801 | IQR | Paired Wilcoxon | p-value | Adjusted | Signif | ||
| (regressive errors) | Median | Median | signed rank test | p-value (Holm) | |||||||
| 2 | 30 | 0.12 | 0.11 | 0.03 | 0.06 | 290 | 0.048 | 0.24 | ns | ||
| 3 | 30 | 0.09 | 0.11 | 0.06 | 0.11 | 239 | 0.234 | 0.702 | ns | ||
| 4 | 30 | 0.09 | 0.11 | 0.11 | 0.11 | 261 | 0.57 | 1 | ns | ||
| 5 | 30 | 0.08 | 0.11 | 0.11 | 0.11 | 231 | 0.984 | 1 | ns | ||
| 6 | 30 | 0.08 | 0.12 | 0.12 | 0.12 | 144 | 0.115 | 0.46 | ns | ||
| Figure 2 | E | p(correct) | n | Saline | IQR | MK-801 | IQR | Paired Wilcoxon | p-value | Adjusted | Signif |
| early | Median | Median | signed rank test | p-value (Holm) | |||||||
| 1 | 30 | 0.76 | 0.24 | 0.61 | 0.42 | 318 | 0.08 | 0.154 | ns | ||
| 2 | 30 | 0.77 | 0.25 | 0.37 | 0.42 | 424 | 1.8e-5 | 9.1e-5 | **** | ||
| 3 | 30 | 0.81 | 0.15 | 0.6 | 0.48 | 352 | 0.013 | 0.039 | * | ||
| 4 | 30 | 0.8 | 0.21 | 0.53 | 0.34 | 384 | 0.001 | 0.004 | ** | ||
| 5 | 30 | 0.76 | 0.23 | 0.71 | 0.32 | 319 | 0.077 | 0.154 | ns | ||
| 6 | 29 | 0.76 | 0.21 | 0.64 | 0.32 | ||||||
| p(correct) | n | Saline | IQR | MK-801 | IQR | Paired Wilcoxon | p-value | Adjusted | Signif | ||
| late | Median | Median | signed rank test | p-value (Holm) | |||||||
| 1 | 30 | 0.85 | 0.17 | 0.67 | 0.56 | 374 | 0.003 | 0.012 | * | ||
| 2 | 30 | 0.87 | 0.14 | 0.38 | 0.35 | 453 | 1.3e-7 | 7.8e-7 | **** | ||
| 3 | 30 | 0.86 | 0.14 | 0.77 | 0.46 | 346.5 | 0.02 | 0.06 | ns | ||
| 4 | 30 | 0.91 | 0.12 | 0.77 | 0.31 | 397 | 3.8e-4 | 0.0019 | ** | ||
| 5 | 30 | 0.87 | 0.13 | 0.86 | 0.21 | 252 | 0.7 | 0.7 | ns | ||
| 6 | 30 | 0.87 | 0.26 | 0.81 | 0.2 | 276 | 0.21 | 0.42 | ns | ||
| Figure 2 | H | p(staying|loss) | n | Optimal | IQR | Suboptimal | IQR | Paired Wilcoxon | p-value | Signif | |
| Median | Median | signed rank test | |||||||||
| Saline | 30 | 0.69 | 0.09 | 0.5 | 0.11 | 465 | 1.86e-9 | **** | |||
| MK-801 | 30 | 0.68 | 0.15 | 0.63 | 0.1 | 335 | 0.034 | * | |||
| Figure 3 | A | model | n | Median | model | Median | n | Paired Wilcoxon signed rank test | p-value | Adjusted | Signif |
| p-value (Holm) | |||||||||||
| 1 | 30 | 276.22 | 2 | 255.28 | 30 | 450 | 2.55e-7 | 1.54e-6 | **** | ||
| 2 | 30 | 255.28 | 3 | 276.23 | 30 | 50 | 5.59e-5 | 3.5e-4 | *** | ||
| 2 | 30 | 255.28 | 4 | 425.21 | 30 | 0 | 1.86e-9 | 1.12e-8 | **** | ||
| 1 | 30 | 276.22 | 3 | 276.23 | 30 | 217 | 0.761 | 1 | ns | ||
| Figure 3 | B | model | Saline | IQR | MK-801 | IQR | Paired Wilcoxon | p-value | Adjusted | Signif | |
| coefficient | Median | Median | signed rank test | p-value (Holm) | |||||||
| α | 30 | 0.78 | 0.16 | 0.36 | 0.695 | 403 | 2.0e-4 | 4.18e-4 | *** | ||
| β | 30 | 2.78 | 1.11 | 1.15 | 0.57 | 461 | 1.3e-8 | 3.9e-08 | **** | ||
| φ | 30 | 0.79 | 0.55 | 1.01 | 0.466 | 118 | 0.018 | 0.018 | * | ||
| Figure 3 | C | model | n | Median | model | Median | n | Paired Wilcoxon | p-value | Adjusted | Signif |
| signed rank test | p-value (Holm) | ||||||||||
| 1 | 30 | 341.85 | 2 | 345.24 | 30 | 63 | 0.542 | 1 | ns | ||
| 2 | 30 | 345.24 | 3 | 344.44 | 30 | 37 | 0.358 | 1 | ns | ||
| 2 | 30 | 345.24 | 4 | 367.6 | 30 | 3 | 6.1e-4 | 0.00366 | ** | ||
| 1 | 30 | 341.85 | 3 | 344.44 | 30 | 25 | 0.091 | 0.546 | ns | ||
| Figure 3 | D | model | Saline | IQR | MK-801 | IQR | Paired Wilcoxon | p-value | Adjusted | Signif | |
| coefficient | Median | Median | signed rank test | p-value (Holm) | |||||||
| α | 14 | 0.968 | 0.082 | 0.842 | 0.102 | 89 | 0.02 | 0.02 | * | ||
| β | 14 | 3.01 | 1.165 | 1.357 | 0.532 | 102 | 6.1e-4 | 0.00183 | *** | ||
| φ | 14 | 0.093 | 0.496 | 0.656 | 0.185 | 5 | 0.001 | 0.002 | ** | ||
| Figure 3 | G | Time-based | n | Saline | IQR | MK-801 | IQR | Paired Wilcoxon | p-value | Adjusted | signif Signif |
| PRL | Median | Median | signed rank test | p-value (Holm) | |||||||
| log latency to | 30 | −0.46 | 0.15 | 0.13 | 0.15 | 6 | 2.61e-8 | **** | |||
| initiate | |||||||||||
| log latency to | 30 | −0.18 | 0.12 | 0.02 | 0.13 | 11 | 1.02e-7 | **** | |||
| response | |||||||||||
| log latency to | 30 | −0.25 | 0.13 | −0.21 | 0.11 | 288 | 0.017 | * | |||
| reward | |||||||||||
| Figure 3 | M | log latency to | 30 | 0.59 | 0.46 | 0.08 | 0.25 | 459 | 2.61e-8 | **** | |
| check | |||||||||||
| Figure 3 | J | Performance | n | Saline | IQR | MK-801 | IQR | Paired Wilcoxon | p-value | Adjusted | Signif |
| based PRL | Median | Median | signed rank test | p-value (Holm) | |||||||
| log latency to | 14 | −0.62 | 0.15 | −0.2 | 0.26 | 11 | 7.01e-5 | *** | |||
| initiate | |||||||||||
| log latency to | 14 | −0.17 | 0.23 | 0 | 0.15 | 1 | 2.44e-4 | *** | |||
| response | |||||||||||
| log latency to | 14 | −0.409 | 0.19 | −3.67 | 0.14 | 27.5 | 0.124 | ns | |||
| reward | |||||||||||
| Figure 3 | K | log latency to | 14 | 0.6 | 0.75 | −0.13 | 1.14 | 67 | 0.391 | ns | |
| check |