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. 2022 Oct 14;12:967450. doi: 10.3389/fonc.2022.967450

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Copyright © 2022 Xia, Wen, Zhou, Li, Lu, Liu and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic alteration of imaging parameters for osteosarcoma patients with different clinical outcomes during treatment period. (A) K^trans , K_ep , and V_e of DCE-MRI before treatment as well as after 1~2 cycles of the treatment. (B) changes of D, D*, ADC and f value of IVIM-DWI before treatment as well as after 1~2 cycles of the treatment. *p <0.05 vs PD, ^# p <0.05 vs SD, ^& p <0.05 vs CR/PR. Comparison for continuous data were analyzed by t test (paired or unpaired) or Mann-Whitney U test.