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. 2022 Oct 14;13:932047. doi: 10.3389/fmicb.2022.932047

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Copyright © 2022 Wang, Wu, Wang, Yang, Bian, Jiang, Lv, Yan, Xia, Han and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Post-antibiotic supplementation with Akkermansia muciniphila worsened the gut barrier and aggravated colonic and systemic inflammation during tumorigenesis. (A) Colonic relative mRNA levels of Tjp1, Ocln, and Cdh1 in the four groups. (B) Colonic relative mRNA expression level of MUC2 in the four groups. (C) Serum LBP level in the four groups. (D) Colonic relative mRNA expression levels of Il1b, Il6, and Tnfa in the four groups. (E) Serum levels of IL-1β, IL-6, and TNF-α in the four groups. Data are shown as means ± SEM. *P < 0.05.