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. 2022 Oct 14;13:930252. doi: 10.3389/fimmu.2022.930252

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Copyright © 2022 Nantel, Bourdin, Adams, Carbonneau, Rabezanahary, Hamelin, McCormack, Savard, Longtin, Cheng, De Serres, Corbeil, Gilca, Baz, Boivin, Quach and Decaluwe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Recovered HCWs who were seronegative prior to vaccination showed suboptimal immune responses after one vaccine dose. (A) SARS-CoV-2 Spike RBD–specific binding IgG levels assessed by ELISA (left panel), SARS-CoV-2 neutralizing antibody titers (middle panel), IFN-γ secreting cells per million in response to SARS-CoV-2 Spike glycoprotein peptides (right panel) assessed by ELISpot for seronegative (Seroneg.) (n=24) and seropositive (Seropos.) (n=31) recovered HCWs after one dose of vaccine. Dashed black lines indicate the positive threshold value, and the percentage of HCWs with responses above positive threshold value is indicated for each condition. Horizontal bars indicate the median of each group. Statistical significance was assessed by Mann-Whitney tests. ***P <.001; ****P <.0001. (B) Pie charts of calculated immunity score for seronegative (left panel) and seropositive (right panel) recovered HCWs after one dose of vaccine.