Fig. 6.

The observed and physiologically based pharmacokinetics (PBPK)–predicted total tissue concentrations with no model adjustment for the lungs, spleen, skeletal muscle, gastrointestinal tract, lymph nodes, brain, kidney, and liver. Red and blue fits represent VIR-7831 and VIR-7831-WT mAb respectively. The solid line (–) fits total mAb in the tissue, the dashed line (----) fits mAb in the interstitial space, and the dotted line (….) fits mAb in serum while solid dots are the experimental values for ⁸⁹Zr antibodies in organs. In the lungs, the dash-dotted line denotes the predicted alveolar epithelial lining fluid concentration