Table 6.
Clinical characteristics of SCCA patients according to HPV genome status.
| Overall population n=39 | Episomal n=14 | Integrated/mixed n=25 | p-value | |
|---|---|---|---|---|
| Gender | ||||
| Male | 7 (17.9%) | 2 (14.3%) | 5 (20%) | 1 |
| Female | 32 (82.1%) | 12 (85.7%) | 20 (80%) | |
| Age | ||||
| Mean (std) | 57.5 (8.4) | 58.6 (6.6) | 56.8 (9.3) | |
| Median (min-max) | 58.2 (38.6-74.9) | 59.8 (46.1-71.7) | 56.1 (38.6-74.9) | 0.6318 |
| Q1-Q3 | 51.4-63.8 | 52.1-63.8 | 49.4-63.7 | |
| Age ≥ 65 | ||||
| No | 32 (82.1%) | 13 (92.9%) | 19 (76%) | 0.3863 |
| Yes | 7 (17.9%) | 1 (7.1%) | 6 (24%) | |
| ECOG | ||||
| 0 | 27 (69.2%) | 9 (64.3%) | 18 (72%) | 0.7232 |
| 1 | 12 (30.8%) | 5 (35.7%) | 7 (28%) | |
| HIV positivity | ||||
| No | 38 (97.4%) | 14 (100%) | 24 (96%) | 1 |
| Yes | 1 (2.6%) | 0 (0%) | 1 (4%) | |
| T | ||||
| Missing (or x) | 8 | 3 | 5 | |
| 0 | 1 (3.2%) | 1 (9.1%) | 0 (0%) | 0.0590 |
| 1 | 1 (3.2%) | 0 (0%) | 1 (5%) | |
| 2 | 13 (41.9%) | 3 (27.3%) | 10 (50%) | |
| 3 | 7 (22.6%) | 1 (9.1%) | 6 (30%) | |
| 4 | 9 (29%) | 6 (54.5%) | 3 (15%) | |
| N | ||||
| Missing (or x) | 11 | 5 | 6 | |
| 0 | 8 (28.6%) | 3 (33.3%) | 5 (26.3%) | 0.4424 |
| 1 | 5 (17.9%) | 0 (0%) | 5 (26.3%) | |
| 2 | 5 (17.9%) | 2 (22.2%) | 3 (15.8%) | |
| 3 | 10 (35.7%) | 4 (44.4%) | 6 (31.6%) | |
| M | ||||
| Missing | 8 | 3 | 5 | |
| 0 | 21 (67.7%) | 6 (54.5%) | 15 (75%) | 0.4232 |
| 1 | 10 (32.3%) | 5 (45.5%) | 5 (25%) | |
| RTCT | ||||
| No | 15 (38.5%) | 8 (57.1%) | 7 (28%) | 0.0727 |
| Yes | 24 (61.5%) | 6 (42.9%) | 18 (72%) | |
| Surgery | ||||
| No | 35 (89.7%) | 13 (92.9%) | 22 (88%) | 1 |
| Yes | 4 (10.3%) | 1 (7.1%) | 3 (12%) | |
| Stage | ||||
| Locally advanced | 4 (10.3%) | 1 (7.1%) | 3 (12%) | 0.0351 |
| Synchronous metastasis | 12 (30.8%) | 8 (57.1%) | 4 (16%) | |
| Metachronous metastasis | 23 (59%) | 5 (35.7%) | 18 (72%) | |
| Invaded sites | ||||
| Mean (std) | 2.4 (1.3) | 2.1 (0.9) | 2.6 (1.4) | |
| Median (min-max) | 2 (1-5) | 2 (1-4) | 2 (1-5) | 0.3314 |
| Q1-Q3 | 01-mars | 01-mars | 01-mars | |
| Invaded sites | ||||
| 1 | 11 (28.2%) | 4 (28.6%) | 7 (28%) | 0.5195 |
| 2 | 12 (30.8%) | 6 (42.9%) | 6 (24%) | |
| 3 | 9 (23.1%) | 3 (21.4%) | 6 (24%) | |
| ≥ 4 | 7 (17.9%) | 1 (7.1%) | 6 (24%) | |
| Best L1 response | ||||
| Complete response | 19 (48.7%) | 8 (57.1%) | 11 (44%) | 0.4310 |
| Partial response | 18 (46.2%) | 5 (35.7%) | 13 (52%) | |
| Stability | 1 (2.6%) | 0 (0%) | 1 (4%) | |
| Progression | 1 (2.6%) | 1 (7.1%) | 0 (0%) | |