Table 7.
Summary of somatic mutations retrieved among SCCA from the HPV02 cohort.
| Gene | Exon | Alteration | Protein | Occurrence |
|---|---|---|---|---|
| PIK3CA | Amplification | n=10 | ||
| 10 | c.1633G>A | p.Glu545Lys | n=6 | |
| ERBB2 | Amplification | n=3 | ||
| 17 | c.1960-1963delATCAinsGTCG | p.Ile654_Ile655delinsValVal | n=3 | |
| CDK4 | Amplification | n=5 | ||
| HRAS | Amplification | n=3 | ||
| 3 | c.121C>T | p.Arg41Trp | n=1 | |
| 3 | c.194G>T | p.Ser65Ile | n=1 | |
| MYOD1 | Amplification | n=4 | ||
| 1 | c.122G>T | p.Arg41Leu | n=1 | |
| CDKN2A | Amplification | n=4 | ||
| TERT | 0 | c.-143C>T (C247T) | n=1 | |
| 0 | c.-124G>A (C228T) | n=1 | ||
| EGFR | Amplification | n=2 | ||
| FBXW7 | 10 | c.1513C>G | p.Arg505Gly | n=1 |
| 11 | c.1805C>T | p.Thr602Ile | n=1 | |
| FGFR1 | Amplification | n=2 | ||
| FGFR2 | Amplification | n=2 | ||
| FGFR3 | Amplification | n=2 | ||
| CTNNB1 | 3 | c.110C>T | p.Ser37Phe | n=1 |
| GNA11 | 4 | c.600C>G | P.Ile200Met | n=1 |
| NRAS | Amplification | n=1 | ||
| RAF1 | Amplification | n=1 |