Table 1.
In vitro susceptibilities (IC50 in nM) of culture-adapted field isolates from Ghana to 11 antimalarial drugs.
| Drug | 3D7 (Mean ± SD) | Field isolates (n=29) | P-value¶ | |
|---|---|---|---|---|
| Mean ± SD | Range | |||
| Artemether | 1.5 ± 0.2 | 1.6 (1.4-2.9)a | 0.9-4.6 | 0.1208b |
| Artesunate | 4.6 ± 0.5 | 3.8 ± 1.5 | 1.0-7.7 | 0.1853c |
| Dihydroartemisinin | 0.6 ± 0.1 | 1.0 ± 0.4 | 0.4-2.1 | 0.0045c** |
| RSA(%)# | 0.6 ± 0.1 | 0.8 ± 0.2 | 0.2-1.2 | 0.2395c |
| Lumefantrine | 2.2 ± 0.3 | 2.7 ± 1.0 | 0.2-4.6 | 0.1923c |
| Mefloquine | 22.0 ± 2.4 | 17.2 ± 4.4 | 6.9-25.2 | 0.0057c** |
| Piperaquine | 5.8 ± 1.5 | 4.6 ± 1.2 | 2.1-7.2 | 0.2947c |
| PSA(%)# | 1.2 ± 0.4 | 1.9 (1.6-2.4)a | 1.3-3.8 | 0.0046b** |
| Naphthoquine | 5.9 ± 0.7 | 7.6 (5.5-10.2)a | 3.4-21.4 | 0.1532b |
| Pyronaridine | 8.6 ± 1.7 | 8.3 ± 2.6 | 3.7-13.1 | 0.8109c |
| Chloroquine | 15.2 ± 1.8 | 14.8 (13.3-18.1)a | 9.4-115.9 | 0.8095b |
| Quinine | 74.9 ± 4.5 | 55.1 ± 24.5 | 8.6-96.7 | 0.0313c* |
| Pyrimethamine | 55.4 ± 5.0 | 7292 (1955-22814)a | 39.1-31407 | 0.0015b** |
aData are not normally distributed and shown as median (IQR).
¶Statistical comparison between the field isolates and 3D7 was performed using Mann-Whitney U test (b) or t-test (c) * and ** indicate significance at P < 0.05 and P < 0.01, respectively.
#RSA and PSA values are percentages (%).