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. 2022 Oct 14;12:992468. doi: 10.3389/fonc.2022.992468

Figure 4.

Figure 4

The correlation between ten cuproptosis-related gene expression levels and various clinicopathological features in hepatocellular carcinoma (HCC) patients using Wilcoxon signed-rank test or Kruskal-Wallis test from the TCGA database. The correlation between various clinicopathological features and cuproptosis-related genes expression levels in HCCs, including ATP7A (A), COA6 (B), TMEM199 (C), ATP6AP1 (D), FDX1 (E), LIPT1 (F), DLAT (G), ACP1 (H), ISCA2 (I), and NDOR1 (J). (ACP1, acid phosphatase 1; ATP6AP1, ATPase H+ transporting accessory protein 1; ATP7A, copper-transporting p-type adenosine triphosphatase 1; COA6, cytochrome c oxidase assembly factor 6; DLAT, dihydrolipoamide S-acetyltransferase; FDX1, ferredoxin 1; G, histologic grade; HCC, hepatocellular carcinoma; ISCA2, iron-sulfur cluster assembly 2; LIPT1, lipoyltransferase 1; M, distant metastasis; N, lymph node metastasis; NDOR1, NADPH dependent diflavin oxidoreductase 1; Stage, clinical stage; T, tumor stage; TCGA, The Cancer Genome Atlas; TMEM199, transmembrane protein 199; *P < 0.05; **P < 0.01; ***P < 0.001).