Table 2.
Outcome Measure | Baseline (T0) Mdn (IQR) |
Post-Training (T1) Mdn (IQR) |
Follow-up (T2) Mdn (IQR) |
Change T0 -T1 Mdn (IQR) |
Change T0 – T2 Mdn (IQR) |
---|---|---|---|---|---|
6MWT (m) | 473.6 | 547.0 | 550.5 | 66.8a | 73.0a |
(376.5,539.0) | (424.8, 589.8) | (431.9, 593.3) | (42.4,93.7) | (45.0,92.1) | |
Steps per Day (count) | 6976.1 | 8187.7 | 8349.0 | 1226.7a | 1368.7a |
(3840.6, 8494.3) | (4427.5, 10,183.4) | (5581.6,10083.1) | (268.2, 2726.7) | (561.0, 3609.0) | |
10 mWT comfortable speed (m/s) | 1.29 | 1.33 | 1.38 | 0.05 | 0.10a |
(1.14,1.37) | (1.26, 1.44) | (1.26, 1.49) | (0.01, 0.11) | (0.00, 0.14) | |
10 mWT fast speed (m/s) | 1.75 | 1.86 | 1.88 | 0.07 | 0.16a |
(1.66, 1.92) | (1.65, 1.93) | (1.73, 2.29) | (−0.01, 0.17) | (0.07, 0.26) | |
TUG-fast speed (sec) | 7.3 | 6.9 | 6.8 | 0.4a | 0.3a |
(6.5, 7.6) | (6.0, 7.5) | (6.2, 7.6) | (0.1, 0.7) | (0.0, 0.6) | |
Stride Length (left) comfortable speed (m) | 1.40 | 1.47 | 1.55 | 0.07 | 0.12a |
(1.26, 1.56) | (1.33, 1.61) | (1.41, 1.63) | (−0.04, 0.18) | (0.00, 0.16) | |
Stride Length (right) comfortable speed (m) | 1.39 | 1.47 | 1.52 | 0.07 | 0.14 |
(1.26, 1.56) | (1.32, 1.60) | (1.41, 1.61) | (−0.05, 0.19) | (−0.00, 0.17) | |
Nonmotor Symptom | 68.5 | 74.5 | 62.5 | 14.5 | 17.0 |
Scale (score) | (51.3, 115.0) | (50.0, 84.5) | (39.5, 91.0) | (−14.8, 33.3) | (−7.8, 30.8) |
MDS-UPDRS Total | 42.3 | 25.0 | 26.0 | 9.8 | 11.25 |
Score | (26.0, 55.4) | (20.5, 43.5) | (21.3, 43.3) | (4.5,18.4)a | (3.0, 15.9) |
MDS-UPDRS Motor Score | 20.3 | 10.0 | 11.0 | 8.0 | 6.3a |
(9.3, 28.8) | (7.25, 16.5) | (8.0, 18.0) | (3.0,12.6) | (2.0,10.0) | |
PFS Score | 41.0 | 43.0 | 49.0 | −2.0 | −.50 |
(23.5, 54.0) | (26.0, 58.3) | (23.0, 59.5) | (−11.8, 2.0) | (−11.5, 1.25) | |
FOG Score | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
(0.0, 14.5) | (0.0, 11.3) | (0.0, 11.3) | (0.0, 2.9) | (0.0, 0.0) | |
Serum BDNF (ng/ml) | 34.8 | 32.3 | 38.7 | −2.1 | 6.8 |
(27.7, 37.3) | (27.3, 36.8) | (31.5, 55.8) | (−6.70, 3.71) | (0.59, 17.8) |
Statistically significant difference following Benjamini-Hochberg correction. Abbreviations: 6 MWT, 6-minute walk test; 10 MWT, 10-meter walk test; TUG, timed up and go; NMS, Non-motor Symptom Scale; MDS-UPDRS, Movement Disorders Society-revised Unified Parkinson's Disease Rating Scale; Mdn, median; IQR, interquartile range.