Fig. 6.

In vivo gene editing efficiency of RNP loaded nanocapsule in mice.Graphicalillustration of the (a) TdTomato gene, (b) site of intravitreal injection in mice eye, (c) ATRA targeted nanocapsule. (d) post injection in vivo gene editing in RPE layer quantified in terms of TdTomato positive area (%) in different treatment groups, (e) mounted RPE layer of the mouse treated with PBS, RNP, NCs and NC-ATRA, herein black area represents TdTomato signals after 12 d treatment. Reprinted by permission from [174]. Copyright ©2019 the authors under exclusive licence to Springer Nature Limited.