. 2022 Oct 27;5(10):e2238880. doi: 10.1001/jamanetworkopen.2022.38880

Table 2. Million Veteran Program MaxAlc Loci Summary Table^a.

Position	MaxAlc wave 2 GWS	Ancestry	Nearest gene	Novel locus	MaxAlc wave 1 GWS	Alcohol use	PAU	AUDIT-P	AUDIT-C	DPW	Locus previously GWS for other related outcomes
4:100239319	rs1229984	E	ADH1B	No	Yes	Yes	Yes	Yes	Yes	Yes	NA
4:100229017	rs2066702	A	ADH1B	No	Yes	Yes	No	No	No	No	NA
4:103188709	rs13107325	E	SLC39A8	No	No	Yes	Yes	Yes	Yes	Yes	Sleep, schizophrenia
17:43810896	rs77804065	E	CRHR1	N	Yes	No	No	No	No	Yes	Neuroticism, feeling guilty
11:47676170	rs7107356	E	AGBL2	Yes	No	No	No	No	No	No	Neuroticism, well-being, prefers bitter alcohol beverage
7:135162897	rs2551763	E	CNOT4	Yes	No	No	No	No	No	No	Educational attainment
1:7830262	rs2153733	E	CAMTA1	Yes	No	No	No	No	No	No	Morningness
19: 37504953	rs826323	C	ZNF420	Yes	No	No	No	No	No	No	Body shape, body mass index
10:10714452	rs145961009	E	RP1-186E20.1	Yes	No	No	No	No	No	No	NA
9:33094361	rs56175925	A	B4GALT1	Yes	No	No	No	No	No	No	Aspartate aminotransferase levels
9:30346448	rs4879424	E	snoU13	Yes	No	No	No	No	No	No	NA
10:110572259	rs1577857	E	RP11-655H13.2	No	Yes	No	Yes	No	No	No	NA
2:104056769	rs6752675	C	AC092568.1	Yes	No	No	No	No	No	No	NA
2:27730940	rs1260326	E	GCKR	No	No	Yes	Yes	No	Yes	Yes	NA
11:113392994	rs2514218	C	DRD2	No	No	Yes	Yes	No	No	No	Depression, neuroticism, well-being

Abbreviations: A, African ancestry; AUDIT-C, Alcohol Use Disorders Identification Test–Consumption; AUDIT-P, Alcohol Use Disorders Identification Test–Problems; C, cross-ancestry; DPW, drinks per week; E, European ancestry; GWS, genome-wide significance; MaxAlc, maximum habitual alcohol intake; NA, not applicable; PAU, problematic alcohol use.

^{^a}

GWS set at P = 5.0 × 10⁻⁸.

Table 2. Million Veteran Program MaxAlc Loci Summary Tablea.

Table 2. Million Veteran Program MaxAlc Loci Summary Table^a.