Figure 2.

MIR145 core promoter-mediated silencing of miR-143/145 cluster in bladder tumors

(A–C) Spearman correlation analysis of (A) MIR145 proximal and core promoter mean methylation, and (B, C) the individual CpG loci methylation with miR-143/145 levels. (D) Boxplots illustrating the methylation of MIR145 promoter CpG loci in bladder tumors and normal adjacent urothelium. ∗∗∗p<0.001 (E–G) Boxplots presenting the correlation of MIR145 promoter mean methylation with muscle-invasive disease (E), tumor stage (F), and tumor grade (G). p-values calculated by Mann-Whitney U test (D, E, G) and Kruskal-Wallis test (F).