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. 2022 Oct 7;30:311–322. doi: 10.1016/j.omtn.2022.10.001

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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MIR145 promoter methylation analysis results in superior clinical benefit of multivariate prognostic models

(A and B) Kaplan-Meier survival curves for the PFS of NMIBC (A) and the OS of MIBC (B) patients according to multivariate models of MIR145 core promoter methylation with EORTC-risk group and tumor stage, respectively. p-values calculated by log-rank test. (C and D) Decision curve analysis of the “control” and the “MIR145 methylation-fitted” multivariate prognostic models for the PFS of NMIBC (C) and OS of MIBC (D) patients.