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. 2022 Oct 27;8(12):1802–1808. doi: 10.1001/jamaoncol.2022.5074

Table 2. Treatment-Related Adverse Events Reported During Follow-up.

Toxic effect Toxic effects by olaparib dose and toxic effect grade, No.a
50 mg Twice daily 100 mg Twice daily 150 mg Twice daily 200 mg Twice daily
1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4
1-y Follow-up (n = 23)
Pain 0 0 0 0 0 1 0 0 1 0 0 0 2 0 0 0
Fibrosis 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Deformity 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Skin hyperpigmentation 0 0 0 0 1 0 0 0 1 0 0 0 1 0 0 0
Telangiectasia 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0
Lymphedema 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
2-y Follow-up (n = 20)
Pain 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0
Fibrosis 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0
Deformity 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Skin hyperpigmentation 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0
Telangiectasia 0 0 0 0 3 0 0 0 0 0 0 0 1 0 0 0
Lymphedema 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0
a

Toxic effect grades are based on Common Terminology Criteria for Adverse Events, version 4.03.9