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. Author manuscript; available in PMC: 2023 Mar 23.
Published in final edited form as: Sci Immunol. 2022 Sep 23;7(75):eabo3170. doi: 10.1126/sciimmunol.abo3170

Figure 5: CXCR4 signaling blockade and effects on Il7 expression and lymphopoiesis in WHIM mice.

Figure 5:

(A) Experimental setup for CXCR4 signaling inhibition in Cxcr4+/+ and Cxcr4WHIM/+ mice for 1 week. (B) Geo. Mean of Il7-GFP in MSC of Cxcr4+/+ and Cxcr4WHIM/+ Il7GFP/+ mice after 1 week of CXCR4 signaling inhibition. (C) Cell numbers of B cell developmental stages in the BM of Cxcr4+/+ and Cxcr4WHIM/+ mice after 1 week of CXCR4 signaling inhibition. Mature B cell numbers in blood (D), spleen (E), and in peripheral lymph nodes (F) of Cxcr4+/+ and Cxcr4WHIM/+ mice after 3 weeks of CXCR4 signaling inhibition. Data are representative of 2 independent experiments with n=4-6 mice. Bars indicate mean, error bars show standard deviation. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 by unpaired two-sided Student’s t-test.