TABLE 1.
Characteristics of studies evaluating the association of NLR and severity
| Author | Year | Participants (male) | Median/mean age (IQR/SD) | NLR description | Type of outcome | NLR mean (SD) in severe patients | NLR mean (SD) in nonsevere patients | SD mean difference between severe and nonsevere patients | OR (adjusted) | HR (adjusted) |
|---|---|---|---|---|---|---|---|---|---|---|
| Chuan Qin et al | 2020 | 452 (235) | 57.5 (14.81) | Quantitative | Severity | 6.1 (4.96) | 3.27 (2.3) | 0.67 [0.48, 0.87] | NR | NR |
| Xiurong Ding et al | 2020 | 72 (33) | 49 0.75 (20) | Quantitative | Severity | 4.8 (5.33) | 2 (1.18) | 1.06 [0.47, 1.66] | NR | NR |
| Yafei Zhang e al. | 2020 | 115 (49) | 49.52 (17.06) | Quantitative | Severity | 758 (7.04) | 2.28 (1.29) | 1.39 [0.94, 1.74] | NR | NR |
| Fengjun Liu et al | 2020 | 134 (63) | 51.25 (20.74) | Quantitative | Severity | 3.85 (2.22) | 2.72 (1.41) | 0.73 [0.23, 1.22] | NR | NR |
| Xiaomin Luo et al | 2020 | 298 (150) | 55.75 (21.48) | Quantitative | Severity | 6.28 (4.17) | 2.68 (1.32) | 1.47 [1.02, 1.93] | NR | NR |
| Mortality | ||||||||||
| Ruchong Chen et al | 2020 | 548 (313) | 56 (14.5) | Quantitative | Severity | 9.89 (9.2) | 3.86 (3.4) | 1.03 [0.83, 1.23] | NR | NR |
| Mortality | ||||||||||
| Hou Keke et al | 2020 | 56 (29) | 48 (13.5) | Quantitative | Severity | 6.13 (6.08) | 4.01 (5.62) | 0.36 [−0.31, 1.04] | NR | NR |
| Changzheng Wang et al | 2020 | 45 (23) | 39 (34.07) | Quantitative | Severity | 29.9 (18.7) | 7.93 (8.36) | 1.90 [1.09, 2.72] | NR | NR |
| Jianhong Fu et al | 2020 | 75 (45) | 46.6 (14) | Quantitative | Severity | 6.29 (3.72) | 2.3 (1.22) | 1.97 [1.33, 2.61] | NR | NR |
| Song CY et al | 2020 | 79 (49) | 54 (45‐63) | Quantitative | Severity | 9.87 (11.3) | 3.35 (2.6) | 0.72 [0.25, 1.19] | NR | NR |
| Lian J. et al | 2020 | 203 (90) | 66 (62‐71) | Quantitative | Severity | 4.18 (2.82) | 2.59 (1.35) | 0.82 [0.51, 1.13] | NR | NR |
| Gormez S et al | 2020 | 247 (154) | 51.3 (14.2) | Quantitative | Severity | 8.13 (5.82) | 3.18 (2.33) | 1.50 [1.15, 1.84] | NR | NR |
| Feng Z et al | 2020 | 141 (72) | 44 (34‐55) | Quantitative | Severity | 4.45 (1.48) | 2.55 (1.18) | 1.56 [0.99, 2.12] | NR | NR |
| Bennouar S et al | 2020 | 330 (206) | 66.6 (8.9) | Quantitative | Severity | 12.7 (10.9) | 5.1 (4.4) | 0.96 [0.73, 1.19] | NR | NR |
| Qun S et al | 2020 | 225 (96) | 59.8 (14) | Quantitative | Severity | 2.96 (2.47) | 2.41 (1.39) | 0.34 [−0.02, 0.70] | NR | NR |
| Xue G et al | 2020 | 114 (64) | 62 (51‐70) | Quantitative | Severity | 6.58 (4.91) | 3.075 (1.86) | 0.93 [0.54, 1.32] | NR | NR |
| Zhichao F et al | 2020 | 141 (72) | 44 (34‐45) | Quantitative | Severity | 5.1 (2.81) | 3.15 (1.48) | 1.17 [0.61, 1.72] | NR | NR |
| Chen et al | 2020 | 132 (76) | 63.4 (56‐71) | Quantitative | Severity | 7.63 (6.97) | 4.475 (3.9) | 0.69 [0.23, 1.14] | NR | NR |
| Mortality | ||||||||||
| Ok F et al | 2020 | 139 (62) | 55.5 (18.5) | Quantitative | Severity | 6.1 (5.1) | 2.46 (2.3) | 0.99 [0.63, 1.35] | NR | NR |
| Basbus L et al | 2020 | 131 (71) | 52 (36‐77) | Qualitative | Severity | NR | NR | NR | 8.73 (2.73‐27.85) a | NR |
| Cheng B et al | 2020 | 456 (211) | 54.97 (18.59) | Quantitative | Severity | 3.615 (2.6) | 2.16 (1.35) | 0.68 [0.49, 0.87] | NR | NR |
| Shi S et al | 2020 | 87 (49) | 60 (22‐88) | Quantitative | Severity | 7.3 (5.97) | 2.2 (0.97) | 1.30 [0.83, 1.77] | NR | NR |
| Asan A et al | 2020 | 695 (331) | NR | Quantitative | Severity | 6.6 (7.8) | 2.4 (2) | 1.69 [1.30, 2.09] | NR | NR |
| Lei Liu et al | 2020 | 294 (162) | 56.0 (39‐67) | Quantitative | Severity | 12.33 (10.45) | 2.85 (2.07) | 1.55 [1.28, 1.83] | NR | NR |
| Hu Haifeng et al | 2020 | 40 (24) | 51.0 (42.0‐66.8) | Quatitative | Severity | 10.59 (12.33) | 3.13 (2.4) | 0.80 [0.16, 1.45] | NR | NR |
| Güner R et al | 2020 | 222 (132) | 50.6 (16.5) | Quantitative | Severity | 12.7 (27) | 8.35 (20.4) | 0.20 [−0.12, 0.51] | NR | NR |
| Gong J et al | 2020 | 189 (88) | 49 (35‐63) | Quantitative | Severity | 4.03 (3.48) | 2.03 (1.11) | 1.19 [0.77, 1.61] | NR | NR |
| Liao D et al | 2020 | 294 (145) | NR | Quantitative | Severity | 4.96 (3.82) | 2.78 (1.78) | 0.73 [0.50, 0.97] | NR | NR |
| Ai‐ping Yang et al | 2020 | 93 (56) | 46.4 (17.6) | NLR < 3 | Severity | 20.7 (24.1) | 4.8 (3.5) | 1.26 [0.76, 1.76] | NR | NR |
| NLR ≥ 3 | ||||||||||
| Weifeng Shang et al | 2020 | 443 (220) | 55.475 (17.4) | NLR ≥ 4.283 | Severity | 5.36 (5.11) | 2.51 (1.59) | 0.9 [0.69, 1.11] | NR | NR |
| NLR < 4.283 | ||||||||||
| Chen Xi et al | 2020 | 139 (76) | 45.5 (13.3) | NLR < 4.5 | Severity | 4.47 (2.99) | 3.31 (1.92) | 0.52 [0.12, 0.93] | NR | NR |
| NLR ≥ 4.5 | ||||||||||
| Xintian Xia et al | 2020 | 63 (33) | NR | NLR < 4.795 | Severity | 12.1 (14.32) | 5.77 (10.2) | 0.50 [0.00, 1.01] | NR | NR |
| NLR > 4.795 | ||||||||||
| Li Long et al | 2020 | 301 (150) | 50.25 (20) | NLR < 2.973 | Severity | NR | NR | NR | NR | 2.641 (1.421‐4.908) P = 0.002* |
| NLR ≥ 2.973 | ||||||||||
| Yue‐Ping Liu et al | 2020 | 84 (47) | 54.25 (52.59) | NLR < 4.87 | Severity | 19.75 (48.96) | 4.3 (7.88) | 0.58 [0.10, 1.07] | NR | NR |
| NLR ≥ 4.87 | ||||||||||
| Suyu Sun et al | 2020 | 116 (60) | 49.5 (11.85) | NLR < 4.5 | Severity | 8.9 (7.9) | 2.5 (1.28) | 1.61 [1.14, 2.09] | NR | NR |
| NLR ≥ 4.5 | ||||||||||
| Chen Xing et al | 2020 | 296 (137) | NR | NR | Severity | 3.86 (3.28) | 1.88 (1.03) | 1.39 [1.00, 1.78] | NR | NR |
Abbreviations: HR, hazard ratio; IQR, interquartile range; NR, not reported NLR, neutrophil‐to‐lymphocyte ratio; OR, odds ratio; SD, standard deviation.
a
Adjusted to age and hypertension.
*
Adjusted to sex, age, comorbidities, eosinophil count and C‐reactive protein level.