Table 2. Summary of the Binding Thermodynamic Parameters for QD-DiMan Binding with DC-SIGN, DC-SIGN-C, and DC-SIGNR (SDs Represent Fitting Errors).
lectina | ΔH°/kJ mol–1 | ΔS°/J mol–1 K–1 | ΔG°/kJ mol–1 |
---|---|---|---|
DC-SIGN | –96.8 ± 0.6 | –161 ± 2 | –48.6 ± 0.9 |
DC-SIGN-C | 2 ± 4 | 174 ± 10 | –50 ± 5 |
DC-SIGNR | –100 ± 10 | –201 ± 34 | –40 ± 20 |
ITC measured ΔH°, ΔS°, and ΔG° values for CRD-DiMan monovalent binding are −25.8 kJ mol–1, 28.5 J K–1 mol–1, and −17.3 kJ mol–1, respectively.43