FIG. 6.

The number of CD4⁺ (A) and CD8⁺ (B) cells following N. caninum infection in BALB/c (□) and IFN-γ-deficient (⋄) mice. The splenocytes were collected from each mouse infected i.p. with 2.5 × 10³ N. caninum tachyzoites at 0, 1, 4, and 7 dpi. Each value is the mean of the cell numbers ± the standard deviation of triplicate samples. According to Student's t test, the differences between BALB/c and IFN-γ-deficient mice were significant (asterisk, P < 0.01). Data are representative of two similar experiments.