Skip to main content
. 2022 Jul 7;122(20):15865–15913. doi: 10.1021/acs.chemrev.1c01031

Figure 7.

Figure 7

A diversity of commonly used labels that can be attached to the reducing end of the glycan. Labeling is performed to enable fluorescence detection (all labels), to improve retention on RP-LC-FLD (2-AA, 2-AB, and 2-PA), to enable separation by introducing a negative charge for CGE-LIF (APTS, ANTS, 2-AA, or 2-PA), or to enhance MS ionization by introducing a tertiary amine through carbamate chemistry (InstantPC, RapiFluor-MS, ProA). 2-AB, 2-AA, and 2-PA can also be used as reactive MALDI matrices as these labels absorb UV light that is in the wavelength range of most common MALDI lasers (330–360 nm).