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. 2022 Oct 14;16:1012422. doi: 10.3389/fnana.2022.1012422

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Copyright © 2022 Hassan, Elnagar, Abdelrazik, Mahdi, Hamza, Elattar, ElNashar, Alghamdi, Al-Qahtani, Al-Khater, Aldahhan and ELdesoqui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical abstract. Naringin improves the cerebellar neurotoxicity induced by AlCl₃ evaluated by decrease of the oxidative stress marker (in the form of decreasing the iNOS); decrease the microtubule assembly marker (Tau protein) and increase the autophagy marker (LC3). AlCl_3, Aluminum chloride; Inos, Inducible nitric oxide synthase; LC3, Light chain 3; GSH, Reduced glutathione; NO, Nitric oxide and MDA, Malondialdehyde.