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. 2022 Oct 14;16:1012422. doi: 10.3389/fnana.2022.1012422

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Copyright © 2022 Hassan, Elnagar, Abdelrazik, Mahdi, Hamza, Elattar, ElNashar, Alghamdi, Al-Qahtani, Al-Khater, Aldahhan and ELdesoqui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical detection of cerebellar tau protein: (A) The control rat showed weak positive tau immunoreaction in a Purkinje cell (arrow). (B) The rat showed negative tau immunoreaction. (C) AlCl₃ group showed a strong positive tau immunoreaction in most Purkinje and granule cells (arrows). (D) The rat treated with combined AlCl₃ and N showed weak positive tau immunoreaction in some Purkinje and granule cells (arrows) (Tau × 400). (E) Area% of tau-positive immune reaction in cerebellar sections of all studied groups. n = 6 in each group. Data were prescribed as mean ± SD. The intergroup variation was conducted by Games-Howell post-hoc test. *p < 0.001 compared with C group. ^#p < 0.001 compared with AlCl_3. ^$p < 0.001 compared with AlCl₃.