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. 2022 Oct 26;8(2):e002575. doi: 10.1136/rmdopen-2022-002575

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Longitudinal vaccine-induced antibody responses by isotypes of vaccinated RA patients compared to healthy controls. (A) Comparison of IgA and IgG responses in RA patients capable of mounting an immune response after vaccination (n=64) and HC at visits T1 and T2. Levels of significance are calculated by unpaired t-test. *p<0.05, **p<0.01, ***p<0.001. (B) Heatmaps summarizing the measured MFI signals normalized to empty bead control (MFI FOE) that visualize IgG, IgA and IgM responses to RBD, S1, S2 and N on different DMARD regimen after the first (T1) and second vaccine dose (T2) and after 12 (T3) and 24 weeks (T4) for HC and RA patients. T1=3 weeks after 1st vaccination, T2=2 weeks after 2nd vaccination, T3=12 weeks after 1st vaccination, T4= 24 weeks after 1st vaccination *p<0.05, **p<0.01, ***p<0.001.