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. 2022 Oct 27;19:263. doi: 10.1186/s12974-022-02623-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Aquaporin-4 (AQP4)–immunoglobulin G(IgG)-induced optic neuritis (ON) rats exhibit severe visual dysfunction. A Experimental time course. Pupillary light reflex (PLR) analysis was conducted on days −1, 2, 7, 14, and 21. B Representative images of the pupil recorded in the PLR experiment at before and 7 days after IgG injection. The dotted line indicates the edge of the pupil. C Quantification of the pupil constriction (%) (Control-IgG: n = 6, AQP4-IgG: n = 5, mean ± SEM, ***p < 0.001, assessed by two-way analysis of variance (ANOVA) followed by Bonferroni test). D Quantification of CTB-labeled axons at 4 mm posterior to the IgG-injected site (Control-IgG: n = 6, AQP4-IgG: n = 5, mean ± SEM, ***p < 0.001 assessed by Student’s t test). E Spearman's correlation coefficient test was used to assess the correlations between the number of CTB-positive axons (day 24) and constriction rate of Pupillary light reflex (day 21) (Control-IgG: n = 6, AQP4-IgG: n = 5)