Table 2.

Levels of ProBNP and NT-proBNP in different clinical scenarios.

In Acute Dyspnea: To identify acute HF (multiple cut off point)      • BNP                  < 100 pg/mL to exclude                                  > 400 pg/mL, to rule in      • NT-proBNP     < 450 pg/mL for age <50 years                                 < 900 pg/mL for age 50-75 years                                 < 1800 pg/mL for age > 75 years To identify acute HF from pleural fluids sample [26]      • NT-proBNP     >1500 pg/mL In Renal Failure with glomerular filtration rate (GFR) <60 mL/min/body surface area (BSA)      • BNP                 <200 pg/mL      • NT-proBNP     <1200 pg/mL In Outpatient Setting:      • BNP                  20 pg/mL (asymptomatic)                                  40 pg/mL (symptomatic)      • NT-proBNP      <50 pg/mL for age    <50 years                                  <75 pg/mL for age 50-75 years                                   <250 pg/mL for age > 75 years

Modified from Kim et al. [25].