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. 2022 Oct 28;23:60. doi: 10.1186/s12868-022-00734-8

Table 4.

Subgroup analysis of treatment effect of scaffold embedded chABC on motor function recovery after SCI compared to non-treated animals

Subgroup Number of experiments Heterogeneity (p value) SMD (95% CI) p value
SCI model
 Contusion-compression 4 87.3% (< 0.0001) 1.4 − 0.52 3.31 0.15
 Transection–hemisection 5 87% (< 0.0001) 2.458 0.688 4.228 0.006
Severity of SCI
 Severe 5 87.8% (< 0.0001) 2.694 0.793 4.595 0.005
 Moderate 4 85.7% (0.001) 1.146 − 0.567 2.858 0.19
Transplantation type
 Injection 5 85.7% (< 0.0001) 1.45 − 0.093 2.997 0.065
 Implant 4 90.0% (< 0.0001) 2.801 0.399 5.204 0.022
Follow-up time
 < 8 weeks 6 67.2% (0.0091) 1.55 0.572 2.527 0.002
 ≥ 8 weeks 3 95.5% (< 0.0000) 3.11 − 0.89 7.1 0.128
 Overall 9 86.8% (< 0.0001) 1.95 0.708 3.198 0.002

CI confidence interval, SCI spinal cord injury, SMD standardized mean difference