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. 2022 Oct 28;20:170. doi: 10.1186/s12964-022-00984-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — MICALL2 upregulation correlates with poor prognosis in human colorectal cancer. A MICALL2 mRNA expression levels in colon adenocarcinoma (COAD) or rectum adenocarcinoma (READ) tissues and normal controls from a TCGA cohort (http://ualcan.path.uab.edu/cgi-bin/ualcan-res.pl). B Kaplan–Meier survival analysis of colon carcinoma patients with either lower (blue) or higher (red) MICALL2 expression derived from TCGA data set (http://gepia.cancer-pku.cn/index.html). C MICALL2 mRNA expression level in 27 pairs of CRC and adjacent non-tumor tissues (Ctr) was determined by qRT-PCR. D Representative IHC staining of MICALL2 in CRC and adjacent non-cancerous colorectal tissues. The positive staining of MICALL2 showed brown, and the nuclei were stained with hematoxylin. E The statistical analysis of MICALL2 expression based on the AOD scores in the CRC (n = 66) and adjacent non-cancerous colorectal tissues (n = 66)