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. 2022 Oct 28;20:170. doi: 10.1186/s12964-022-00984-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — TRIM21 is negatively correlated to MICALL2 and reversely regulates the tumorigenic activity of MICALL2 in CRC. A Downregulated TRIM21 mRNA levels in CRC datasets from GEO platform (https://www.ncbi.nlm.nih.gov/geo/). B Correlation between TRIM21 and MICALL2 mRNA levels in CRC from TCGA CRC cohort, using GEPIA tool. C Representative IHC staining for TRIM21 and MICALL2 in colorectal cancer TMA serial sections. Scale bar are shown as indicated. D Negative correlation between TRIM21 and MICALL2 IHC scores in CRC tissues (n = 73). The correlation coefficient (R) and P value based on Pearson’s product-moment correlation analysis are shown. E Western blotting was performed to detect the expression of MICALL2 and TRIM21 in the stable MICALL2-silenced HCT8 transfected with siRNA targeting TRIM21, and GAPDH was used as loading control. F Growth curves of MICALL2-silenced HCT8 cell line transfected with siRNA targeting TRIM21. G Representative images (left) and quantification of wound area (right) of gap closure of MICALL2-silenced HCT8 transfected with siRNA targeting TRIM21