Table 2.

List of selected endomiRs

MiRNA	Target protein	Pathophysiological effect
miR-10a (24)↓ miR-146a (25) ↓ miR-185 (26) ↑	NFκB ↑ NOX-4 ↑ GPx-1 ↓	Increased oxidative stress Increased oxidative stress Increased oxidative stress
miR-92a (27) ↓ miR-125a-5p a (28) ↑ miR-217 (29) ↑	TNF-α-receptor 1 ↑ eNOS ↓ SIRT-1 ↓	Reduced nitric oxide availability Reduced nitric oxide availability Reduced nitric oxide availability
miR-19a (30) ↑ miR-21 (31) ↑ miR-100 (32) ↑	cyclin D1 ↓ β–galactosidase ↑ NrF-2 ↓	Accelerated cellular senescence Accelerated cellular senescence Accelerated cellular senescence
miR-34a (33) ↑ miR-124 (35) ↓ miR-199a-5p (34) ↑	SIRT-1 ↓ PTBP1 ↑ AMPK ↓	Dysregulated energy metabolism Dysregulated energy metabolism Dysregulated energy metabolism
miR-126 (36) ↓ miR-155 (37) ↓ miR-205 (38) ↑	VCAM-1 ↑ AT1 receptor ↑ TIMP-3 ↓	Increased chronic inflammation Increased chronic inflammation Increased chronic inflammation

↑ / ↓ indicate a pathological up- or downregulation in case of endothelial dysfunction

^a Effects of miR-125a-5p on eNOS (endothelial nitric oxide synthase) have only been demonstrated in mouse models so far