Figure 2.
Timeline of cefiderocol-resistant NDM-1-producing Klebsiella pneumoniae-positive cultures during a tertiary care hospital outbreak in Florence, Italy, August 2021–June 2022 (n = 21 patients)
FDC: cefiderocol; ICU: intensive care unit; NDM-Kp: NDM-1-producing Klebsiella pneumoniae.
CirA alterations, hospital wards, the NDM-Kp source specimen, and the eventual cefiderocol treatment were reported for each patient. Thirteen of 15 patients, positive for a CirAY253CfsTer5 mutant, exhibited epidemiological links (overlapping period in the same ward) with the index case (Pt2) or among each other.
