Table 2.

Relationship between sarcopenia and adverse effects during conversion therapy in GC-CY₁ patients.

Adverse effects	Pre-treatment		p	Post-treatment		p	ΔSMI (%)/50 days			p
	Sarcopenia(n=7)	No-sarcopenia(n=29)		Sarcopenia(n=13)	No-sarcopenia(n=23)		SML(n=8)		No-SML(n=28)
Leukopenia
Yes/No	3/4	5/24	0.167*	5/8	3/20	0.107*	6/2	2/26		<0.001*
≥3 grade/<3grade	2/5	0/29	0.033*	2/13	0/23	0.149*	2/6	0/28		0.044*
Neutropenia
Yes/No	4/3	3/26	0.016*	4/9	3/20	0.225*	5/3	2/26		0.003*
≥3 grade/<3grade	2/5	0/29	0.033*	1/12	1/22	1.000*	2/6	0/28		0.044*
Thrombocytopenia
Yes/No	3/4	1/28	0.018*	4/9	0/23	0.012*	4/4	0/28		0.001*
≥3 grade/<3grade	0/7	0/29	1.000*	0/13	0/23	1.000*	0/8	0/28		1.000*
Decreased hemoglobin
Yes/No	1/6	0/29	0.194*	1/12	0/23	0.361*	1/7	0/28		0.222*
≥3 grade/<3grade	0/7	0/29	1.000*	0/13	0/23	1.000*	0/8	0/28		1.000*
Nausea/vomiting
Yes/No	5/2	4/25	0.006*	5/8	4/19	0.235*	7/1	2/26		<0.001*
≥3 grade/<3grade	2/5	0/29	0.033*	1/12	1/22	1.000*	2/6	0/28		0.044*
Diarrhea
Yes/No	1/6	0/29	0.194*	1/12	0/23	0.361*	1/7	0/28		0.222*
≥3 grade/<3grade	0/7	0/29	1.000*	0/13	0/23	1.000*	0/8	0/28		1.000*
Anorexia
Yes/No	2/5	1/28	0.090*	3/10	0/23	0.040*	3/5	0/28		0.008*
≥3 grade/<3grade	0/7	0/29	1.000*	0/13	0/23	1.000*	0/8	0/28		1.000*
Peripheral sensory neuropathy
Yes/No	1/6	0/29	0.194*	1/12	0/23	0.361*	1/7	0/28		0.222*
≥3 grade/<3grade	0/7	0/29	1.000*	0/13	0/23	1.000*	0/8	0/28		1.000*
AST/ALT increased
Yes/No	0/7	1/28	1.000*	1/12	0/23	0.361*	0/8	1/27		1.000*
≥3 grade/<3grade	0/7	0/29	1.000*	0/13	0/23	1.000*	0/8	0/28		1.000*
Proteinuria
Yes/No	2/5	2/27	0.163*	3/10	1/22	0.124*	2/6	2/26		0.207*
≥3 grade/<3grade	0/7	0/29	1.000*	0/13	0/23	1.000*	0/8	0/28		1.000*
Oral mucositis
Yes/No	1/6	0/29	0.194*	0/13	1/22	1.000*	1/7	0/28		0.222*
≥3 grade/<3grade	0/7	0/29	1.000*	0/13	0/23	1.000*	0/8	0/28		1.000*
Fatigue
Yes/No	2/5	1/28	0.090*	3/10	0/23	0.040*	3/5	0/28		0.008*
≥3 grade/<3grade	1/6	0/29	0.194*	1/12	0/23	0.361*	1/7	0/28		0.222*

According to Common Terminology Criteria for Adverse Events (version 3.0). AST, aspartate transaminase; ALT, alanine aminotransferase. *Fisher’s exact test.