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. Author manuscript; available in PMC: 2023 Sep 21.
Published in final edited form as: Cell Syst. 2022 Aug 17;13(9):690–710.e17. doi: 10.1016/j.cels.2022.07.006

Figure 6. MYC activation destabilizes NE states.

Figure 6.

(A) Transcription factor network adapted from Wooten et al. to incorporate MYC activity.

(B) In silico destabilization of NE specialists by MYC activation. Using BooleaBayes simulations (Wooten et al., 2019), we performed random walks with activated MYC and found that SCLC-A and SCLC-A2 states are destabilized; i.e., MYC activation is capable of increasing plasticity of these subtypes in RPM tumors. SCLC-N and SCLC-Y attractors were not destabilized.