Table 1.

Archetypes with associated PNEC-related tasks and the cancer hallmark functions they optimize^a

Archetype	Associated PNEC task	Optimized function for increased tumor fitness
SCLC-A	Proliferation	Increased cell proliferationb
SCLC-A2	Neuro- and immuno-modulatory signaling	Evading immune destruction and tumor-promoting inflammation
SCLC-N	Slithering and axon-like protrusions	Activating invasion and metastasisb
SCLC-P	Chemosensation and metabolism	Reprogramming energy metabolism
SCLC-Y	Transdifferentiation to non-NE state in response to injury	Inducing angiogenesis and resisting cell death

^aAll enriched Cancer Hallmark Gene Sets are shown in Table S4.

^bCancer hallmark is inferred from GO term enrichment rather than the enrichment of Cancer Hallmark Gene Sets.