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. 2022 Oct 12;14(42):48011–48028. doi: 10.1021/acsami.2c13156

Figure 9.

Figure 9

Characteristics of platelets labeled with different types of SPION by CLSM and AAS. Platelets (red) stained with anti-CD42 antibody fluorescent for CLSM imaging showed no aggregation in the (A) absence of particles, whereas (B) Resovist showed strong aggregation/activation induced by (C) TRAP, a positive control, and (D–G) variation of platelet sizes induced by SPION. (H) Quantification of the size of platelets after labeling with SPION showed the largest size of platelets caused by SP1, followed by SP2 and SP3, and the smallest size by Resovist and platelet alone. Strong activation of platelets by TRAP and SP4 did not allow quantification of platelet sizes, and they linked to each other. (I) The iron concentration, which was uptaken inside the platelets determined by AAS showed the highest value for SP2, followed by Resovist, lower for SP1 and SP3, and lowest for platelets without particles added.