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. 2022 Jun 13;32(6):e13097. doi: 10.1111/bpa.13097

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© 2022 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Role of the blood–brain‐barrier in PVS in PSEN1 p.Glu280Ala FAD, SAD and CADASIL. Representative images of leaking (full arrow‐head) and non‐leaking (empty arrow‐head) vessels in PSEN1 FAD (n = 21), SAD (n = 10) and CADASIL (n = 10) are shown (A). PSEN1 FAD and SAD cases presented with significantly less leaking vessels than CADASIL cases (B) (p values: **** ≤ 0.0001, *** ≤ 0.001). Further in PSEN1 FAD significantly less dilated vessels were leaking (C) (p value: **** ≤ 0.0001). The % of fibrinogen leaking vessels is significantly correlated with age of onset in PSEN1 familial Alzheimer's disease but not in CADASIL (D) (p value: 0.014 vs. 0.211, r = 0.526, 0.433).