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. 2022 Oct 14;13:1011669. doi: 10.3389/fendo.2022.1011669

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Copyright © 2022 Du, Shi, Xiong, Wang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Canagliflozin improves oxidative stress and mitochondrial damage induced by high glucose. (A) The images and (B) fluorescence intensity of intracellular ROS stained by DCFH-DA (Scale bar: 400 µm). (C) Content of PCO; Activities of (D) SOD and (E) CAT in H9C2 cells of each group. (F) The images and (G) JC-1 fluorescence ratio of MMP analyzed by JC-1 kit (Scale bar: 200 µm). (H) Content of ATP. ROS, reactive oxygen species; PCO, protein carbonyl; SOD, superoxide dismutase; CAT, catalase; MMP, mitochondrial membrane potential; ATP, adenosine triphosphate. (**: P<0.01; ***: P<0.001; compared with CON group; ##: P<0.01; ###: P<0.001; compared with HG group.).