Figure 6.

Schematic illustration of Cana alleviating ferroptosis in diabetic cardiomyopathy. High glucose, as pivotal pathogenic factors of DCM, inhibit the expression of SLC7A11 and promote the expression of TfR1, which in turn decrease the GSH levels and increase the labile iron levels, respectively. These alterations lead to increased lipid peroxidation and cardiomyocyte ferroptosis, which then initiates cardiac dysfunction, eventually leads to the DCM. Cana promotes upregulation of SLC7A11 and downregulation of TfR1 and FTN-H, which protect the cardiomyocytes from ferroptosis. TfR1, transferrin receptor 1; ROS, Reactive Oxygen Species; GSSG, oxidized glutathione; GSH, glutathione; GPX4, glutathione peroxidase 4; MMP, mitochondrial membrane potential; ATP, adenosine triphosphate.