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Toxicities during CAR-T therapy. (A) The structure of CAR. (B) Pathogenesis of CRS. (C) Organ systemic toxicities induced by CRS. Abbreviations: CAR, chimeric antigen receptor; CRS, cytokine release syndrome; ICANS, immune effector cell-associated neurotoxicity syndrome; scFv, single-chain variable fragment; IL, interleukin; IFN-γ, interferon gamma; GM-CSF, granulocyte macrophage colony-stimulating factor; TNF-α, tumor necrosis factor alpha. This figure created with BioRender.com.
