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. 2022 Oct 14;13:950923. doi: 10.3389/fphar.2022.950923

FIGURE 2.

FIGURE 2

Pathogenesis of ICANS during CAR-T therapy. Abbreviations: CAR, chimeric antigen receptor; CRS, cytokine release syndrome; ICANS, immune effector cell-associated neurotoxicity syndrome; IL, interleukin; IFN-γ, interferon gamma; GM-CSF, granulocyte macrophage colony-stimulating factor; TNF-α, tumor necrosis factor alpha; BBB, blood brain barrier. This figure created with BioRender.com.