Table 1.
Comparison of patient characteristics in different weight categories
| Overall | Underweighta | Normal/healthy weightb | Overweightc | Obesed | p Value between all four weight categories | |
|---|---|---|---|---|---|---|
| N | 105 | 9 (9%) | 67 (64%) | 19 (18%) | 10 (10%) | |
| Age, years, (median, IQR) | 20.5 (11.9, 25.7) | 20.5 (14.4, 25.1) | 18.9 (11.3, 24.0) | 22.7 (13.4, 29.6) | 20.6 (9.3, 26.6) | 0.21 |
| Female, N (%) | 48 (46%) | 6 (7%) | 30 (45%) | 7 (37%) | 5 (50%) | 0.51 |
| Sweat chloride (mmol/L) (median, IQR) | 94 (83, 104) | 88.0 (81.5, 94.0) | 97.0 (88.8, 104.6) | 91.0 (82.5, 102.5) | 71.0 (68.5, 87.5) | 0.008 |
| Pancreatic enzyme replacement, N (%) | 87 (83%) | 8 (89%) | 58 (87%) | 18 (95%) | 3 (30%) | <0.001 |
| Oral, nasogastric, or gastrostomy tube supplemental feedings, N (%) | 39 (37%) | 6 (67%) | 29 (43%) | 2 (11%) | 2 (20%) | 0.009 |
| CFRD, N (%) | 16 (15%) | 5 (56%) | 7 (10%) | 4 (21%) | 0 (0%) | 0.002 |
| Insulin use, N (%) | 10 (10%) | 3 (33%) | 5 (7%) | 2 (11%) | 0 (0%) | 0.062 |
| Ivacaftor | 19 (18%) | 1 (11%) | 10 (15%) | 3 (16%) | 5 (50%) | 0.053 |
| Ivacaftor/tezacaftor or ivacaftor/lumacaftor, N (%) | 37 (35%) | 5 (56%) | 18 (27%) | 10 (53%) | 4 (40%) | 0.098 |
| Annual pulmonary exacerbation rate (median, IQR) | 1.0 (0.63, 1.60) | 1.0 (0.53, 1.88) | 1.2 (0.60, 1.80) | 1.0 (0.67, 1.33) | 1.3 (0.63, 1.60) | 0.93 |
| FEV1, % predicted (median, IQR) | 81.2 (62.3, 92.2) | 49.0 (33.0, 68.5) | 80.7 (65.0, 91.3) | 83.7 (68.5, 93.0) | 92.0 (83.6, 102.9) | 0.002 |
| FVC, % predicted (median, IQR) | 88.0 (76.9, 101.0) | 76.5 (48.1, 84.9) | 88.0 (78.4, 100.4) | 93.7 (76.3, 108.9) | 93.3 (86.8, 105.3) | 0.051 |
| FEV1/FVC (median, IQR) | 0.79 (0.70, 0.85) | 0.62 (0.41, 0.78) | 0.80 (0.70, 0.85) | 0.77 (0.65, 0.84) | 0.83 (0.79, 0.90) | 0.008 |
| FEF25–75, % predicted (median, IQR) | 67.7 (42.5, 91.8) | 31.6 (11.3, 47.8) | 62.7 (36.7, 86.6) | 71.0 (31.6, 91.9) | 80.5 (66.0, 103.3) | 0.004 |
Abbreviations: BMI, body mass index; CFRD, cystic fibrosis‐related diabetes; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; IQR, interquartile range.
a
Children with BMI below 5th percentile, adults with BMI below 18.5.
b
Children with BMI 5th to less than the 85th percentile, adults with BMI 18.5–24.9.
c
Children with BMI 85th to less than the 95th percentile, adults with BMI 25.0–29.9.
d
Children with BMI equal to or greater than 95th percentile, adults with BMI 30.0 and above.