. 2022 Oct 28;5(6):e910. doi: 10.1002/hsr2.910

Table 2.

Comparison between children and adults with CF

	Overall	Children (6–19 years of age)	Adults (≥20 years of age)	Children versus adults p Value
N	105	48 (46%)	57 (54%)	N/A
Age, years, (median, IQR)	20.5 (11.9, 25.7)	11.4 (8.5, 14.8)	24.8 (22.3, 29.5)	<0.001
Female, N (%)	48 (46%)	25 (52%)	23 (4%)	0.32
Pancreatic enzyme replacement, N (%)	87 (83%)	38 (79%)	49 (86%)	0.51
Sweat Chloride (median, IQR)	94 (83, 104)	92.8 (78.3, 86.0)	96.0 (86.0, 105.5)	0.51
CFRD, N (%)	16 (15%)	4 (8%)	12 (21%)	0.13
Insulin, N (%)	10 (10%)	2 (4%)	8 (14%)	0.17
Oral, nasogastric, or gastrostomy tube supplemental feedings, N (%)	39 (37%)	21 (44%)	18 (32%)	0.28
Underweight, N (%)^a	9 (9%)	2 (4%)	7 (12%)	0.26
Normal/healthy weight, N (%)^b	67 (64%)	37 (77%)	30 (53%)	0.02
Overweight, N (%)^c	19 (18%)	2 (4%)	17 (30%)	0.002
Obese, N (%)^d	10 (9%)	7 (15%)	3 (5%)	0.20
Annual exacerbation rate (median, IQR)	1.0 (0.63, 1.60)	1.0 (0.7, 1.6)	1.2 (0.6, 1.6)	0.76
FEV₁% predicted (median, IQR)	81.2 (62.3, 92.2)	86.9 (77.6, 95.7)	70.8 (49.7, 87.8)	<0.001
FVC % predicted (median, IQR)	88.0 (76.9, 101.0)	93.0 (80.9, 103.8)	84.5 (73.2, 98.2)	0.052
FEV₁/FVC (median, IQR)	0.79 (0.70, 0.85)	0.84 (0.80, 0.87)	0.72 (0.59, 0.80)	<0.001
FEF25–75% predicted (median, IQR)	67.7 (42.5, 91.8)	76.7 (57.9, 92.9)	45.9 (20.0, 74.4)	<0.001

Abbreviations: BMI, body mass index; CF, cystic fibrosis; CFRD, cystic fibrosis‐related diabetes; FEV₁, forced expiratory volume in 1 s; FVC, forced vital capacity; IQR, interquartile range.

^{^a}

Children with BMI below 5th percentile, adults with BMI below 18.5.

^{^b}

Children with BMI 5th to less than the 85th percentile, adults with BMI 18.5–24.9.

^{^c}

Children with BMI 85th to less than the 95th percentile, adults with BMI 25.0–29.9.

^{^d}

Children with BMI equal to or greater than 95th percentile, adults with BMI 30.0 and above.