Treatment algorithm for patients with HBeAg positive and HBeAg negative chronic hepatitis B based upon AASLD guidelines. Adapted from NA Terrault, AS Lok, BJ McMahon, et al. Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance. Hepatology. 2018 Apr; 67(4): 1560–1599, with permission.