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. 2021 Oct 1;2(4):450–459. doi: 10.1016/j.bpsgos.2021.09.004

Figure 6.

Figure 6

PF–Purkinje cell LTD is impaired in patDp/+ mice. (A) Typical PF-induced EPSCs in wild-type and patDp/+ Purkinje cells recorded before (black traces) and 30 minutes after (colored traces) tetanization using a LTD protocol, a 1-Hz train of stimuli over 5 minutes where each stimulus consists of a PF burst of 8 pulses at 100 Hz followed by 1 climbing fiber stimulation 120 ms after the first PF pulse. Scales = 100 pA, 20 ms. (B) Time graph showing PF-EPSC mean ± SEM amplitudes monitored during baseline (0–10 min) and post-tetanization (15–45 min) periods in wild-type (n = 5) and patDp/+ (n = 7) cells. Relative to wild-type, PF-LTD was impaired in patDp/+ cells, which instead underwent long-term potentiation. In the presence of CX546, an allosteric AMPA receptor modulator, patDp/+ cells show a rescued PF-LTD (n = 6). ∗p < .05, ∗∗p < .01, ∗∗∗p < .005. Average traces show mean ± SEM. All data are noted in the text and legends as mean ± SEM. EPSC, excitatory postsynaptic current; LTD, long-term depression; PF, parallel fiber.