Table 1.
Overview of the Studies Included in the AUD Meta-analysis
| Study | Alcohol Diagnosis | Criteria | AUD Group (Males), N (n) | Control Group (Males), N (n) | Mean Age AUD/Control Groups, Years | p-Value Threshold | Adult Sample |
|---|---|---|---|---|---|---|---|
| Asensio et al., 2016 (13) | Abuse | DSM-IV | 24 (24) | 24 (24) | 35.62/31.91 | Cluster corr. p < .05 | Yes |
| Chanraud et al., 2007 (14) | Dependence | DSM-IV | 26 (26) | 24 (24) | 47.70/45.00 | FDR corr. p < .005 | Yes |
| Charlet et al., 2014 (31) | Dependence | DSM-IV | 33 (25) | 33 (25) | 44.80/46.10 | FWE corr. p < .05 | Yes |
| Demirakca et al., 2011 (28) | Dependence | DSM-IV/ICD-10 | 50 (27) | 66 (34) | 46.60/45.00 | FWE corr. p < .05 | Yes |
| Fein et al., 2006 (85) | Dependence | DSM-IV | 43 (24) | 58 (21) | 46.46/44.62 | FWE corr. p < .05 | Yes |
| Galandra et al., 2018 (15) | Dependence | DSM-IV | 23 (14) | 18 (10) | 45.69/44.83 | Monte Carlo corr. p < .025 | Yes |
| Grodin et al., 2013 (16) | Dependence | DSM-IV | 37 (21) | 69 (47) | 40.20/36.60 | Monte Carlo corr. p < .01 | Yes |
| Guggenmos et al., 2017 (17) | Dependence | DSM-IV/ICD-10 | 119 (101) | 97 (81) | 45.00/43.70 | FWE corr. p < .05 | Yes |
| Jang et al., 2007 (18) | Dependence | DSM-IV | 20 (20) | 20 (20) | 43.50/44.50 | FDR corr. p < .005 | Yes |
| Mechtcheriakov et al., 2007 (19) | Dependence | ICD-10 | 22 (14) | 22 (14) | 53.60/53.70 | FDR corr. p < .05 | Yes |
| Nurmedov et al., 2016 (20) | AUD | DSM-V | 24 (20) | 29 (23) | 40.79/37.45 | FWE corr. p < .05 | Yes |
| Rando et al., 2011 (21) | Dependence | DSM-IV | 45 (35) | 50 (28) | 38.20/31.14 | FWE corr. p < .025 | Yes |
| Segobin et al., 2014 (22) | Dependence | DSM-IV | 19 (17) | N/A | 44.40/46.70 | FDR corr. p < .01 | Yes |
| van Holst et al., 2012 (23) | AUD | DSM-IV | 36 (36) | 54 (54) | 43.20/35.30 | FDR corr. p < .05 | Yes |
| Wang et al., 2018 (24)a | Dependence | DSM-IV | 35 (35) | 33 (33) | 41.80/42.88 | FWE corr. p < .05 | Yes |
| Wang et al., 2018 (24)a | Dependence | DSM-IV | 21 (21) | 33 (33) | 45.95/42.88 | FWE corr. p < .05 | Yes |
| Wiers et al., 2015 (25) | Dependence | DSM-IV | 22 (22) | 21 (21) | 42.14/41.95 | FWE corr. p < .05 | Yes |
| Wu et al., 2018 (26)a | Dependence | DSM-IV | 13 (8) | 22 (13) | 44.10/44.90 | FWE corr. p < .05 | Yes |
| Wu et al., 2018 (26)a | Dependence | DSM-IV | 9 (5) | 22 (13) | 47.00/44.90 | FWE corr. p < .05 | Yes |
| Yoon et al., 2017 (86) | AUD | DSM-IV | 20 (20) | 25 (25) | 28.70/25.40 | Monte Carlo corr. p < .05 | Yes |
| Zois et al., 2017 (27) | Dependence | DSM-IV | 95 (71) | 87 (71) | 45.90/45.90 | FWE corr. p < .05 | Yes |
| Brooks et al., 2014 (33) | Dependence | DSM-IV | 58 (25) | 58 (25) | 14.90/14.70 | FWE corr. p < .05 | No |
AUD, alcohol use disorder; Corr., corrected; FDR, false discovery rate; FWE, familywise error; N/A, not available.
a
Only reported results for AUD subgroups, and each subgroup was entered as a separate study.