Table 2.
Overview of the Studies Included in the OCD Meta-analysis
| Study | Criteria | OCD Group (Males), N (n) | Control Group(Males), N (n) | Mean Age OCD/Control Groups, Years | p-Value Threshold | Adult Sample |
|---|---|---|---|---|---|---|
| Christian et al., 2008 (50) | DSM-IV | 14 (N/A) | 21 (15) | 38/38.9 | Uncorr. p < .001 | Yes |
| Gilbert et al., 2008 (36) | DSM-IV | 25 (13) | 20 (9) | 37.5/29.8 | FDR corr. p < .05 | Yes |
| Gonçalves et al., 2017 (57) | DSM-IV | 15 (11) | 15 (9) | 31.7/30 | Uncorr. p < .001 | Yes |
| Hashimoto et al., 2014 (37)a | DSM-IV | 24 (11) | 30 (14) | 35.7/32.5 | FDR corr. p < .05 | Yes |
| Hashimoto et al., 2014 (37)a | DSM-IV | 15 (7) | 30 (14) | 32.5/32.5 | FDR corr. p < .05 | Yes |
| Hoexter et al., 2012 (38) | DSM-IV | 38 (15) | 36 (13) | 31.5/27.8 | FWE corr. p < .05 | Yes |
| Hou et al., 2013 (39) | DSM-IV | 33 (18) | 33 (18) | 25.3/25 | FWE corr. p < .05 | Yes |
| Ikari et al., 2017 (55) | DSM-IV | 92 (42) | 146 (61) | 36.3/35 | FWE corr. p < .05 | Yes |
| Kobayashi et al., 2015 (40) | DSM-IV | 20 (10) | 30 (15) | 34.1/31.2 | FDR corr. p < .05 | Yes |
| Kopřivová et al., 2009 (41) | ICD-10 | 14 (5) | 15 (6) | 28.6/28.7 | FDR corr. p < .05 | Yes |
| Lv et al., 2017 (42) | DSM-IV | 95 (52) | 95 (49) | 30/30.4 | Monte Carlo corr. p < .05 | Yes |
| Matsumoto et al., 2010 (43) | DSM-IV | 16 (7) | 32 (14) | 32.8/32.6 | Uncorr. p < .001 | Yes |
| Moon and Jeong, 2018 (58) | DSM-IV | 18 (11) | 18 (11) | 27.6/30.7 | FWE corr. p < .05 | Yes |
| Moreira et al., 2017 (59) | DSM-IV | 40 (13) | 40 (13) | 26.3/26.5 | FWE corr. p < .05 | Yes |
| Pujol et al., 2004 (44) | DSM-IV | 72 (40) | 72 (40) | 29.8/30.1 | Corr. p < .05 | Yes |
| Real et al., 2016 (45) | DSM-IV | 124 (62) | 112 (62) | 34.9/33.8 | FWE corr. p < .05 | Yes |
| Riffkin et al., 2005 (87) | DSM-IV | 18 (8) | 18 (8) | 36.1/34.6 | Cluster corr. p < .05 | Yes |
| Spalletta et al., 2014 (88) | DSM-IV | 20 (12) | 20 (12) | 33.1/35.2 | Uncorr. p < .001 | Yes |
| Subirà et al., 2013 (54)a | DSM-IV | 30 (20) | 95 (55) | 32.2/33.9 | FWE corr. p < .05 | Yes |
| Subirà et al., 2013 (54)a | DSM-IV | 65 (29) | 95 (55) | 34.6/33.9 | FWE corr. p < .05 | Yes |
| Tan et al., 2013 (51) | DSM-IV | 28 (19) | 22 (15) | 25.4/27.9 | Uncorr. p < .001 | Yes |
| Tang et al., 2015 (46) | DSM-IV | 26 (15) | 32 (17) | 25.5/26.2 | FWE corr. p < .05 | Yes |
| Tang et al., 2016 (52) | DSM-IV | 18 (11) | 16 (10) | 27.3/26.8 | Monte Carlo corr. p < .01 | Yes |
| Togao et al., 2010 (47) | DSM-III and DSM-IV | 23 (9) | 26 (12) | 32.6/31.3 | FDR corr. p < .05 | Yes |
| Valente et al., 2005 (48) | DSM-IV | 19 (10) | 15 (7) | 32.7/32.3 | Uncorr. p < .001 | Yes |
| Wang et al., (53) 2018 | DSM-IV | 22 (11) | 22 (11) | 22.2/22.7 | Monte Carlo corr. p < .05 | Yes |
| Yoo et al., 2008 (49) | DSM-IV | 71 (47) | 71 (47) | 26.6/26.7 | Uncorr. p < .001 | Yes |
| Cabrera et al., 2019 (89) | DSM-IV | 14 (10) | 14 (10) | 11.1/11.1 | Uncorr. p < .005 | No |
| Carmona et al., 2007 (90) | DSM-IV | 18 (13) | 18 (13) | 12.9/13 | FWE corr. p < .05 | No |
| Cheng et al., 2016 (91) | DSM-IV | 30 (18) | 30 (18) | 10.8/10.5 | FWE corr. p < .05 | No |
| Gilbert et al., 2008 (92) | DSM-IV | 10 (6) | 10 (6) | 12.9/13.4 | FDR corr. p < .05 | No |
| Jayarajan et al., 2015 (93) | DSM-IV | 15 (8) | 15 (8) | 14.1/14.3 | FWE corr. p < .05 | No |
| Lázaro et al., 2009 (94) | DSM-IV | 15 (8) | 15 (8) | 13.7/14.3 | FWE corr. p < .05 | No |
| Lázaro et al., 2014 (95) | DSM-IV | 62 (36) | 46 (22) | 15.4/15.3 | FWE corr. p < .05 | No |
| Szeszko et al., 2008 (96) | DSM-IV | 37 (14) | 26 (9) | 13/13 | FWE corr. p < .05 | No |
AUD, alcohol use disorder; Corr., corrected; FDR, false discovery rate; FWE, familywise error; N/A, not available; OCD, obsessive-compulsive disorder; Uncorr., uncorrected with a cluster spatial extent.
a
Only reported results for AUD subgroups, and each subgroup was entered as a separate study.