Table 3.
Dominant Model z-Score Meta-analysis
| Reference | Country | Duration | N | Average Age, Years | Scales Assessed | Measure | OR (95% CI)a | z Score | Stouffer’s z | p Value |
|---|---|---|---|---|---|---|---|---|---|---|
| Cheon et al., 2009 (16) | Korea | 8 weeks | 114 | 9 | ADHD-RS-IV, CGI-I | ≥50% ADHD-RS-IV reduction | 2.26 (0.67–7.62) | 1.32 | 3.03 | .002 |
| Huang et al., 2018 (25) | Taiwan | 4 weeks | 59 | 11 | SNAP-IV | ≥50% SNAP-IV reduction | 3.45 (0.36–32.90) | 1.08 | ||
| Unal et al., 2016 (11) | Turkey | 4–6 weeks | 108 | 10 | CGI-S, GAS, CPT, TMT-A/B, CPRS, CTRS | ≥50% improvement on any CPRS/CTRS subscale and GAS ≥60 and ≥2 points improvement in CGI-S | 0.89 (0.40–2.00) | −0.28 | ||
| Polanczyk et al., 2007 (14) | Brazil | 1 and 3 months | 106 | 10 | SNAP-IV | Δ SNAP-IV | 2.89 (1.40–5.97) | 2.88 | ||
| da Silva et al., 2008 (15) | Brazil | 4 weeks | 59 | 12 | SNAP-IV | Δ SNAP-IV | 3.50 (1.27–9.66) | 2.41 | ||
| Contini et al., 2011 (17) | Brazil | 4 weeks | 165 | 35 | SNAP-IV, CGI-S | ≥30% SNAP-IV reduction and CGI-S and CGI-S ≤2 | 1.07 (0.44–2.58) | 0.00 |
Stouffer’s z score for improved outcomes in G-allele carriers relative to CC subjects.
ADHD-RS-IV, ADHD Rating Scale-IV; CGI-I, Clinical Global Impressions–Improvement; CGI-S, CGI–Severity; CI, confidence interval; CPRS, Conners’ Parent Rating Scale; CTRS, Conners’ Teacher Rating Scale; GAS, Global Assessment of Functioning Scale; OR, odds ratio; SNAP-IV, Swanson, Nolan, and Pelham Version-IV Scale; TMT, Trail Making Test.
a
Odds of improved outcome among carriers of rs1800544.